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Networks & cell functioning - GARMeN

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-  Discrete event networks are used to study the combinatorics of incoming signals in discrete event networks. We explore the specificities of the Signal language and the associated model-checking tool-based Sigali, which manipulates ILTS: Implicit Labeled Transition Systems (which can be seen as an equational representation of an automaton). Both Signal and Sigali are developed at Irisa.
-  Qualitative differential models appear to be appropriate to study genetically regulated metabolisms such as lipid metabolism.
-  Qualitative differential models are also used to assess if qualitative experimental measurements about two steady states of a biological process are compatible with what is known about the interactions among the targets. The method consists in comparing qualitative data to the predictions of a qualitative behavioral regulation model, represented by a labelled oriented graph called the interaction graph. The interaction graph is interpreted qualitatively as a linear system in the sign algebra.

These approaches are embedded in a graphical analyzer tool named GARMeN : graphical analyzer tool for genetic and biological networks, generation of MatLab simulation models, analysis based on qualitative methods.


see online : Irisa’s Symbiose project

last update : 28/07/2005

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